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In the context of a client receiving IV morphine sulfate, monitoring respiration first is critical due to the respiratory depressant effects of opioids. Morphine can significantly decrease the respiratory rate, leading to inadequate ventilation and potential respiratory failure.

Opioids like morphine can cause histamine release, which may influence blood pressure and pulse, but the most immediate risk presented by morphine administration is its impact on the respiratory system. Patients receiving opioids must be closely monitored for signs of sedation and respiratory depression, hence respirations are prioritized. Early detection of respiratory compromise is essential to intervene promptly and ensure patient safety.

Other vital signs, like blood pressure, temperature, and pulse rate, while important, do not carry the same immediate risk in this scenario as the rate and quality of respiration. Monitoring these other parameters is certainly part of comprehensive patient assessment, but assessing respiratory function takes precedence when opioid therapy is initiated.